The physiological control of eating: signals, neurons, and networks

AG Watts, SE Kanoski, G Sanchez-Watts… - Physiological …, 2022 - journals.physiology.org
During the past 30 yr, investigating the physiology of eating behaviors has generated a truly
vast literature. This is fueled in part by a dramatic increase in obesity and its comorbidities …

Protein appetite as an integrator in the obesity system: the protein leverage hypothesis

D Raubenheimer, SJ Simpson - … Transactions of the …, 2023 - royalsocietypublishing.org
Despite the large volume and extensive range of obesity research, there is substantial
disagreement on the causes and effective preventative strategies. We suggest the field will …

FGF21 acts in the brain to drive macronutrient-specific changes in behavioral motivation and brain reward signaling

MSH Khan, SQ Kim, RC Ross, F Corpodean… - Molecular …, 2025 - Elsevier
Objective Dietary protein restriction induces adaptive changes in food preference,
increasing protein consumption over carbohydrates or fat. We investigated whether …

Protein appetite at the interface between nutrient sensing and physiological homeostasis

MS Khan, RA Spann, H Münzberg, S Yu, VL Albaugh… - Nutrients, 2021 - mdpi.com
Feeding behavior is guided by multiple competing physiological needs, as animals must
sense their internal nutritional state and then identify and consume foods that meet …

Investigating the effect of physiological need states on palatability and motivation using microstructural analysis of licking

F Naneix, KZ Peters, JE McCutcheon - Neuroscience, 2020 - Elsevier
The study of consummatory responses during food intake represents a unique opportunity to
investigate the physiological, psychological and neurobiological processes that control …

Dietary protein restriction diminishes sucrose reward and reduces sucrose-evoked mesolimbic dopamine signaling in mice

CT Wu, DG Magaña, J Roshgadol, L Tian, KK Ryan - Appetite, 2024 - Elsevier
A growing literature suggests manipulating dietary protein status decreases sweet
consumption in rodents and in humans. Underlying neurocircuit mechanisms have not yet …

Dietary protein restriction modulates 'dessert'intake after a meal, via fibroblast growth factor 21 (FGF21)

CT Wu, KR Larson, LC Sims, KK Ryan - Physiology & Behavior, 2023 - Elsevier
Pharmacological administration of fibroblast growth factor 21 (FGF21) alters food choice,
including that it decreases the consumption of sucrose and other sweet tastants. Conversely …

FGF21 as a mediator of adaptive changes in food intake and macronutrient preference in response to protein restriction

SQ Kim, RA Spann, MSH Khan, HR Berthoud… - …, 2024 - Elsevier
Free-feeding animals navigate complex nutritional landscapes in which food availability,
cost, and nutritional value can vary markedly. Animals have thus developed neural …

[HTML][HTML] Restriction of dietary protein in rats increases progressive-ratio motivation for protein

G Chiacchierini, F Naneix, J Apergis-Schoute… - Physiology & …, 2022 - Elsevier
Low-protein diets can impact food intake and appetite, but it is not known if motivation for
food is changed. In the present study, we used an operant behavioral task–the progressive …

The limitations of investigating appetite through circuit manipulations: are we biting off more than we can chew?

J Wang, K Beecher, F Chehrehasa… - Reviews in the …, 2023 - degruyter.com
Disordered eating can underpin a number of debilitating and prevalent chronic diseases,
such as obesity. Broader advances in psychopharmacology and biology have motivated …