Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a
high morbidity additionally, CRC patients may develop liver metastasis, which is the major …

DNA methylation is one of the most important epigenetic mechanisms to regulate gene
expression, which is highly dynamic during development and specifically maintained in …

DNA methylation is one of the most important epigenetic mechanisms that governing
regulation of gene expression, aberrant DNA methylation patterns are strongly associated …

Abstract Background Lysine crotonylation (Kcr) is up-regulation in colorectal cancer (CRC)
tissues, while its specific contribution remains uncertain. This study aimed to elucidate the …

Background Tertiary lymphoid structures (TLSs) have been proposed to assess the
prognosis of patients with cancer. Here, we investigated the prognostic value and relevant …

Anoikis and epithelial-mesenchymal transition (EMT) are significant phenomena occurring
in distant metastasis of colon adenocarcinoma (COAD). A comprehensive understanding of …

Background It has been reported that long non-coding RNAs (lncRNAs) can be regarded as
a biomarker and had particular clinical significance for early screening and gastric cancer …

Background Colorectal cancer (CRC) is one of the most common malignant tumors with a
poor prognosis. At present, the pathogenesis is not completely clear. Therefore, finding …

Epigenetic mechanisms play a pivotal role in controlling gene expression and cellular
plasticity in both normal physiology and pathophysiological conditions. These mechanisms …

Gastrointestinal (GI) cancers have been considered primarily genetic malignancies, caused
by a series of progressive genetic alterations. Accumulating evidence shows that histone …