Mechanical induction in metazoan development and evolution: from earliest multi-cellular organisms to modern animal embryos

NM Nguyen, E Farge - Nature Communications, 2024 - nature.com
The development and origin of animal body forms have long been intensely explored, from
the analysis of morphological traits during antiquity to Newtonian mechanical conceptions of …

Role of local angiotensin II signaling in bladder function

HA Anderson, GL Robilotto… - American Journal of …, 2024 - journals.physiology.org
Angiotensin II signaling plays a crucial role in many different diseases. Although it has been
known for several decades that local angiotensin II signaling molecules are present in the …

Precise control of transmembrane current via regulating bionic lipid membrane composition

Z Shang, J Zhao, M Yang, Y Xiao, W Chu, S Xu… - Science …, 2024 - science.org
The transport of ions through biological ion channels is regulated not only by their structural
characteristics but also by the composition of the phospholipid membrane, which serves as …

Structural Rearrangement of the AT1 Receptor Modulated by Membrane Thickness and Tension

B Poudel, JM Vanegas - The Journal of Physical Chemistry B, 2024 - ACS Publications
Membrane-embedded mechanosensitive (MS) proteins, including ion channels and G-
protein coupled receptors (GPCRs), are essential for the transduction of external mechanical …

All-Atom Simulations Reveal the Effect of Membrane Composition on the Signaling of the NKG2A/CD94/HLA-E Immune Receptor Complex

M Ljubič, A Perdih, J Borišek - Journal of chemical information …, 2024 - ACS Publications
Understanding how membrane composition influences the dynamics and function of
transmembrane proteins is crucial for the comprehensive elucidation of cellular signaling …

Mechanical stress and anionic lipids synergistically stabilize an atypical structure of the angiotensin II type 1 receptor (AT1)

R Ben Boubaker, D Henrion… - PLoS Computational …, 2024 - journals.plos.org
Environmental factors, including mechanical stress and surrounding lipids, can influence the
response of GPCRs, such as the mechanosensitive angiotensin II type 1 receptor (AT1). To …

Regulation of transmembrane current through modulation of biomimetic lipid membrane composition

Z Shang, J Zhao, M Yang, Y Xiao, W Chu, Y Cai… - Faraday …, 2025 - pubs.rsc.org
Ion transport through biological channels is influenced not only by the structural properties of
the channels themselves but also by the composition of the phospholipid membrane, which …

A Hierarchical Mechanotransduction System: From Macro to Micro

R Cao, H Tian, Y Tian, X Fu - Advanced Science, 2024 - Wiley Online Library
Mechanotransduction is a strictly regulated process whereby mechanical stimuli, including
mechanical forces and properties, are sensed and translated into biochemical signals …

Mechanical force activates the light-dependent channels TRP and TRPL in excised patches from the rhabdomere of Drosophila photoreceptors

R Delgado, CAM Wilson, L Caballero, F Melo… - Neuroscience, 2024 - Elsevier
Drosophila phototransduction in light-sensitive microvilli involves a metabotropic signaling
cascade. Photoisomerized rhodopsin couples to G-protein, activating phospholipase C …

Effect of osmotic pressure on membrane permeation through antimicrobial peptide-induced pores

M Ahmed, MM Billah, M Yamazaki - Biochemical and Biophysical Research …, 2025 - Elsevier
Most antimicrobial peptides (AMPs) induce membrane damage such as pore formation in
bacterial cells, resulting in rapid cell death. On the other hand, bacterial cells have a large …