Cerebrospinal fluid-contacting neurons: multimodal cells with diverse roles in the CNS

C Wyart, M Carbo-Tano, Y Cantaut-Belarif… - Nature Reviews …, 2023 - nature.com
The cerebrospinal fluid (CSF) is a complex solution that circulates around the CNS, and
whose composition changes as a function of an animal's physiological state. Ciliated …

Design of mechanosensory feedback during undulatory locomotion to enhance speed and stability

C Wyart, M Carbo-Tano - Current Opinion in Neurobiology, 2023 - Elsevier
Undulatory locomotion relies on the propagation of a wave of excitation in the spinal cord
leading to consequential activation of segmental skeletal muscles along the body. Although …

Topography of the GLP-1/GLP-1 receptor system in the spinal cord of male mice

Y Ruska, A Csibi, B Dorogházi, A Szilvásy-Szabó… - Scientific Reports, 2024 - nature.com
Abstract Glucagon-like peptide-1 receptor (GLP-1R) agonists are now commonly used to
treat type 2 diabetes and obesity. GLP-1R signaling in the spinal cord has been suggested …

[HTML][HTML] Volume electron microscopy for genetically and molecularly defined neural circuits

N Ohno, F Karube, F Fujiyama - Neuroscience Research, 2024 - Elsevier
The brain networks responsible for adaptive behavioral changes are based on the physical
connections between neurons. Light and electron microscopy have long been used to study …

Endogenous opioid signalling regulates spinal ependymal cell proliferation

WWS Yue, KK Touhara, K Toma, X Duan, D Julius - Nature, 2024 - nature.com
After injury, mammalian spinal cords develop scars to confine the lesion and prevent further
damage. However, excessive scarring can hinder neural regeneration and functional …

Unraveling the roles of cerebrospinal fluid-contacting neurons

C Wyart - Elife, 2023 - elifesciences.org
Locomotion: Unraveling the roles of cerebrospinal fluid-contacting neurons | eLife Skip to
Content eLife logo eLife home page Menu Home Magazine Community About Search Alerts …

SCO-spondin knockout mice exhibit small brain ventricles and mild spine deformation

H Xu, GP Dugué, Y Cantaut-Belarif, FX Lejeune… - Fluids and Barriers of …, 2023 - Springer
Reissner's fiber (RF) is an extracellular polymer comprising the large monomeric protein
SCO-spondin (SSPO) secreted by the subcommissural organ (SCO) that extends through …

Insights into the mechanisms of neuron generation and specification in the zebrafish ventral spinal cord

G Cucun, M Köhler, S Pfitsch, S Rastegar - The FEBS Journal, 2024 - Wiley Online Library
The vertebrate nervous system is composed of a wide range of neurons and complex
synaptic connections, raising the intriguing question of how neuronal diversity is generated …

The Reissner fiber under tension in vivo shows dynamic interaction with ciliated cells contacting the cerebrospinal fluid

C Bellegarda, G Zavard, L Moisan, F Brochard-Wyart… - Elife, 2023 - elifesciences.org
The Reissner fiber (RF) is an acellular thread positioned in the midline of the central canal
that aggregates thanks to the beating of numerous cilia from ependymal radial glial cells …

[HTML][HTML] CRISPR/CasRx suppresses KRAS-induced brain arteriovenous malformation developed in postnatal brain endothelial cells in mice

S Saito, Y Nakamura, S Miyashita, T Sato… - JCI …, 2024 - pmc.ncbi.nlm.nih.gov
Brain arteriovenous malformations (bAVMs) are anomalies forming vascular tangles
connecting the arteries and veins, which cause hemorrhagic stroke in young adults. Current …