The crucial role of cancer stem cells (CSC s) in the pathology of malignant diseases has
been extensively studied during the last decade. Nestin, a class VI intermediate filament …

Despite a continuing debate about the existence of cancer stem cells (CSCs), recent
discoveries have provided further support for their existence and their roles in drug …

The cancer stem cell (CSC) hypothesis, despite the limitations of the currently available
models and assays, has ushered in a new era of excitement in cancer research. The …

Soft tissue sarcomas (STSs) are an uncommon group of solid tumors that can arise
throughout the human lifespan. Despite their commonality as non-bony cancers that develop …

The three most frequent pediatric sarcomas, ie, Ewing's sarcoma, osteosarcoma, and
rhabdomyosarcoma, were examined in this study: three cell lines derived from three primary …

Background Sarcomas are rare tumors but represent the third most common malignancy in
children. The cancer stem cell (CSC) paradigm is well established, and CSCs have been …

Abstract Three‐dimensional (3D) cancer tumor models are becoming vital approaches for
high‐throughput drug screening, drug targeting, development of novel theranostic systems …

Soft tissue sarcomas (STS) are a rare group of mesenchymal solid tumors with
heterogeneous genetic profiles and clinical features. Systemic chemotherapy is the …

Objective: Osteosarcomas (OS) is one the most common primary bone malignancy in
humans with the lungs metastasis in most cases. Metastasis and recurrence of OS is …

The Notch pathway regulates a broad spectrum of cell fate decisions and differentiation
processes during fetal and postnatal development. In addition, the Notch pathway plays an …