The functions, purposes, and roles of metallothioneins have been the subject of
speculations since the discovery of the protein over 60 years ago. This article guides …

Nearly sixty years ago Fredrich Timm developed a histochemical technique that revealed a
rich reserve of free zinc in distinct regions of the brain. Subsequent electron microscopy …

Zinc, an essential micronutrient for life, was first discovered in 1869 and later found to be
indispensable for the normal development of plants and for the normal growth of rats and …

Vesicular transporters (VTs) define the type of neurotransmitter that synaptic vesicles (SVs)
store and release. While certain mammalian neurons release multiple transmitters, it is not …

Atherosclerosis is a complex disease that can lead to life-threatening events, such as
myocardial infarction and ischemic stroke. Despite the severity of this disease, diagnosing …

Abstract Zinc (Zn 2+) is an essential micronutrient that is required for a wide variety of
cellular processes. Tools and methods have been instrumental in revealing the myriad roles …

A large percentage of transcription factors require zinc to bind DNA. In this review, we
discuss what makes p53 unique among zinc-dependent transcription factors. The …

The disruption of homeostasis of zinc (Zn2+) and copper (Cu2+) ions in the central nervous
system is involved in the pathogenesis of many neurodegenerative diseases, such as …

Zinc is an essential micronutrient required for all domains of life. Cells maintain zinc
homeostasis using a network of transporters, buffers, and transcription factors. Zinc is …

Zinc is a highly abundant cation in the brain, essential for cellular functions, including
transcription, enzymatic activity, and cell signaling. However, zinc can also trigger injurious …