The problem of antibiotic resistance is on the rise, with multidrug-resistant strains emerging
even to the last resort antibiotics. The drug discovery process is often stalled by stringent cut …

Antimicrobial peptides (AMPs) are short oligopeptides that can penetrate the bacterial inner
and outer membranes. Together with cell-penetrating peptides (CPPs), they are called …

Gram-negative bacteria are intrinsically resistant to many classes of antibiotics,
predominantly due to the impermeability of the outer membrane and the presence of efflux …

Among multiple approaches to combating antimicrobial resistance, a combination therapy of
existing antibiotics with bacterial membrane‐perturbing agents is promising. A viable …

There has been a resurgence in the clinical use of polymyxin antibiotics such as colistin due
to the limited treatment options for infections caused by carbapenem-resistant …

The rise of antibiotic resistance among skin-infecting pathogens poses an urgent threat to
public health and has fueled the search for new therapies. Enhancing the potency of …

Abstract The New Delhi β-Lactamase 1 (NDM-1), one of the most prevalent types of metallo-
β-lactamases, has attracted extensive attention since its discovery. Extensive efforts have …

People with cystic fibrosis (CF) suffer from recurrent bacterial infections which induce
inflammation, lung tissue damage and failure of the respiratory system. Prolonged exposure …

Catheter-associated urinary tract infections (CAUTIs) pose a significant challenge in hospital
settings. Current solutions available on the market involve incorporating antimicrobials and …

Membrane-targeting compounds are of immense interest to counter complicated multi-drug
resistant infections. However, the broad-spectrum effect of such compounds is often unmet …