Autoimmune diseases are a diverse group of conditions characterized by aberrant B cell
and T cell reactivity to normal constituents of the host. These diseases occur widely and …

Autoreactive B cells and interferons are central players in systemic lupus erythematosus
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …

Patients with systemic lupus erythematosus (SLE) display a complex blood transcriptome
whose cellular origin is poorly resolved. Using single-cell RNA sequencing, we profiled …

Research elucidating the pathogenesis of systemic lupus erythematosus (SLE) has defined
two critical families of mediators, type I interferon (IFN-I) and autoantibodies targeting nucleic …

While systemic lupus erythematosus (SLE) is an autoantibody and immune complex disease
by nature, most of its organ manifestations are in fact inflammatory. SLE activity scores thus …

Notable advances in gene sequencing methods in recent years have permitted enormous
progress in the phenotypic and genotypic characterization of autoinflammatory syndromes …

Emerging evidence supports that mitochondrial dysfunction contributes to systemic lupus
erythematosus (SLE) pathogenesis. Here we show that programmed mitochondrial removal …

Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with a clear
genetic component. While most SLE patients carry rare gene variants in lupus risk genes …

Although all multicellular organisms have germ line–encoded innate receptors to sense
pathogen-associated molecular patterns, vertebrates also evolved adaptive immunity based …

Systemic lupus erythematosus is the prototypical systemic autoimmune disease, as it is
characterized both by protean multi-organ system manifestations and by the uniform …