The free radical nitric oxide (· NO) is a key mediator in different physiological processes such
as vasodilation, neurotransmission, inflammation, and cellular immune responses, and thus …

Although nitric oxide (NO) was identified more than 150 years ago and its effects were
clinically tested in the form of nitroglycerine, it was not until the decades of 1970–1990 that it …

Nitric oxide (NO) inhibits the mitochondrial respiratory chain, resulting in inhibition of ATP
production, increased oxidant production and increased susceptibility to cell death. NO …

New discoveries in the last decade significantly altered our view on mitochondria. They are
no longer viewed as energy-making slaves but rather individual cells-within-the-cell. In …

Significance: Mitochondrial ion channels/transporters and the electron transport chain (ETC)
serve as key sensors and regulators for cellular redox signaling, the production of reactive …

We used laser scanning confocal microscopy in combination with the nitric oxide (NO)‐
sensitive fluorescent dye DAF‐2 and the reactive oxygen species (ROS)‐sensitive dyes CM …

Heart mitochondria play a central role in cell energy provision and in signaling. Nitric oxide
(NO) is a free radical with primary regulatory functions in the heart and involved in a broad …

This paper reviews the current ideas on nitric oxide (NO) physiology in brain and other
mammalian organs and on the subcellular distribution of nitric oxide synthases (NOS) …

Regulation of intramitochondrial free calcium ([Ca2+] m) is critical in both physiological and
pathological functioning of the heart. The full extent and importance of the role of [Ca2+] m is …

Abstract Connexin 43 (Cx43), which is highly expressed in the heart and especially in
cardiomyocytes, interferes with the expression of nitric oxide synthase (NOS) isoforms …