Vascular ageing, characterized by structural and functional changes in blood vessels of
which arterial stiffness and endothelial dysfunction are key components, is associated with …

Significance: The vasculature responds to the respiratory needs of tissue by modulating
luminal diameter through smooth muscle constriction or relaxation. Coronary perfusion …

Aortic stiffness is a hallmark of cardiovascular disease, but its pathophysiology remains
incompletely understood. This study presents an in-dept characterization of aortic aging in …

Persistently unrepaired DNA damage has been identified as a causative factor for vascular
ageing. We have previously shown that a defect in the function or expression of the DNA …

DNA damage is a causative factor in ageing of the vasculature and other organs. One of the
most important vascular ageing features is reduced nitric oxide (NO) soluble guanylate …

Phosphodiesterases regulate levels of the cyclic nucleotides cyclic adenosine
monophosphate and cyclic guanosine monophosphate. Thanks to regulation by specific …

Cardiovascular diseases are the number one cause of death globally. The most important
determinant of cardiovascular health is a person's age. Aging results in structural changes …

Abstract Background and Purpose Calcitonin gene‐related peptide (CGRP) is a potent
vasodilator. While its signalling is assumed to be mediated via increases in cAMP, this study …

Age-related cardiovascular diseases (CVDs) remain among the leading global causes of
death, and vascular smooth muscle cell (VSMC) remodeling plays an essential role in its …

Ischemic cardiovascular disease and stroke remain the leading cause of global morbidity
and mortality. While aging, protective mechanisms in the body gradually deteriorate …