Research on astronaut health and model organisms have revealed six features of
spaceflight biology that guide our current understanding of fundamental molecular changes …

Recent studies have established that dysregulation of the human immune system and the
reactivation of latent herpesviruses persists for the duration of a 6-month orbital spaceflight …

Spaceflight induces an immune response in astronauts. To better characterize this effect, we
generated single-cell, multi-ome, cell-free RNA (cfRNA), biochemical, and hematology data …

Microgravity is associated with immunological dysfunction, though the mechanisms are
poorly understood. Here, using single-cell analysis of human peripheral blood mononuclear …

Over the course of a mission to the International Space Station (ISS) crew members are
exposed to a number of stressors that can potentially alter the composition of their …

The field of human space travel is in the midst of a dramatic revolution. Upcoming missions
are looking to push the boundaries of space travel, with plans to travel for longer distances …

Latent viral reactivation is a commonly reported manifestation of immune system
dysregulation during spaceflight. As physical fitness and exercise training have been shown …

Maintenance of astronaut health during spaceflight will require monitoring and potentially
modulating their microbiomes. However, documenting microbial shifts during spaceflight has …

The upcoming exploration missions will imply a much longer duration than any of the
missions flown so far. In these missions, physiological adaptation to the new environment …

Latent herpes virus reactivation has been demonstrated in astronauts during shuttle (10–16
days) and International Space Station (≥ 180 days) flights. Following reactivation, viruses …