After the first demonstration 30 years ago that Ca2+ could permeate through two different
channels, the occurrence and role of T-type Ca2+ current, ICaT have been the matter of …

The past 5 years has witnessed an advance in our understanding of alpha1G (Ca v 3.1),
alpha1H (Ca v 3.2), and alpha1l (Ca v 3.3), the pore-forming subunits of T-type or low …

The orderly contraction of the vertebrate heart is determined by generation and propagation
of cardiac action potentials (APs). APs are generated by the integrated activity of time-and …

Painful diabetic neuropathy occurs in approximately 20% of diabetic patients with underlying
pathomechanisms not fully understood. We evaluated the contribution of the Ca V 3.2 …

Cardiovascular diseases (CVDs) are widespread in the modern world, and their number is
constantly growing. For a long time, CVDs have been the leading cause of morbidity and …

L-type and R-type Ca 2+ currents were detected in frog semicircular canal hair cells. The
former was noninactivating and nifedipine-sensitive (5μM); the latter, partially inactivated …

Both L-and T-type calcium channels are present in the heart. In cardiac myocytes L-type
calcium channels are blocked by the classical calcium channel blockers, while T-type …

Cardiac arrhythmias are a major cause of morbidity and mortality in the industrialized world.
Among their treatment regimens one can find the calcium channel antagonists (CCAs), the …

With the increase of our knowledge on cardioactive agents it comes more and more clear
that practically none of the currently used compounds shows absolute selectivity to one or …

Many microalgae produce compounds that exhibit potent biological activities. Ingestion of
marine organisms contaminated with those toxins results in seafood poisonings. In many …