Among the common types of glycoproteins that are found in eukaryotic cells, both as cell
surface proteins and as secreted proteins, are those having N-linked or asparagine-linked …

N-linked glycosylation, a common co-translational modification in eukaryotic cells, involves
the transfer of a lipid-linked oligosaccharide onto asparagine residues in a tripeptide sequon …

Oxidative stress has been implicated in protein phosphorylation and dephosphorylation in
cells. In our current studies, H 2 O 2 was shown to reversibly inhibit protein tyrosine …

Publisher Summary This chapter focuses on the inhibitors of proteins glycosylation acting at
the level of lipid-linked saccharides formation, compounds that interfere with stages after the …

The key step in the asparagine‐linked glycosylation of secretory proteins is the transfer of
oligosaccharide from a dolichol precursor to the polypeptide at an Asp‐X‐Ser/Thr (NXS/T) …

The asparagine-linked oligosaccharides of chick embryo fibroblast glycoproteins were
previously shown to derive from a common lipid-linked precursor, Glc3Man9GlcNAc2. The …

Publisher Summary Inhibitors of specific metabolic reactions can be valuable tools for
studying complex biochemical pathways. This chapter discusses various inhibitors that affect …

Mannose-6-phosphate (M6P) is an essential precursor for mannosyl glycoconjugates,
including lipid-linked oligosaccharides (LLO; glucose3mannose9GlcNAc2-PP-dolichol) …

The potential role of degradative mechanisms in controlling the level of the dolichyl
pyrophosphate-linked Glc3Man9GlcNAc2 required for protein N-glycosylation has been …

Estrogen rapidly, preferentially and markedly enhances the rate of N-linked glycoprotein
synthesis in mouse uteri. In contrast, the rate of glycoprotein turnover is unaffected by the …