Patterns of replication within eukaryotic genomes correlate with gene expression, chromatin
structure, and genome evolution. Recent advances in genome-scale mapping of replication …

DNA replication is central to cell proliferation. Studies in the past six decades since the
proposal of a semiconservative mode of DNA replication have confirmed the high degree of …

At each cell division in humans, 30,000–50,000 DNA replication origins are activated, and it
remains unclear how they are selected and recognized by replication factors. DNA …

The onset of genomic DNA synthesis requires precise interactions of specialized initiator
proteins with DNA at sites where the replication machinery can be loaded. These sites …

DNA replication is tightly controlled in eukaryotic cells to ensure that an exact copy of the
genetic material is inherited by both daughter cells. Oscillating waves of cyclin-dependent …

One of the long-standing questions in eukaryotic DNA replication is the mechanisms that
determine where and when a particular segment of the genome is replicated. Cdc7/Hsk1 is …

Most current evidence indicates that DNA polymerases ε and δ, respectively, perform the
bulk of leading and lagging strand replication of the eukaryotic nuclear genome. Given that …

DNA replication in eukaryotic cells initiates from multiple replication origins that are
distributed throughout the genome. Coordinating the usage of these origins is crucial to …

Abstract OriDB (http://www. oridb. org/) is a database containing collated genome-wide
mapping studies of confirmed and predicted replication origin sites. The original database …

In all kingdoms of life, DNA is used to encode hereditary information. Propagation of the
genetic material between generations requires timely and accurate duplication of DNA by …