Introduction: Adjuvants are used to improve vaccine immunogenicity and efficacy by
enhancing antigen presentation to antigen-specific immune cells with the aim to confer long …

For decades infections have been treated easily with drugs. However, in the 21st century,
they may become lethal again owing to the development of antimicrobial resistance …

The RTS, S vaccine has recently been recommended for implementation as a childhood
vaccine in regions with moderate-to-high malaria transmission. We discuss mechanisms of …

Adjuvants are substances added to vaccines to improve their immunogenicity. Used for
more than 80 years, aluminum, the first adjuvant in human vaccines, proved insufficient to …

Background Vaccine adjuvants are compounds that significantly enhance/prolong the
immune response to a co-administered antigen. The limitations of the use of aluminium salts …

Early data emerging from the first phase 3 trial of a malaria vaccine are raising hopes that a
licensed vaccine will soon be available for use in endemic countries, but given the relatively …

The development of virus-like particle (VLP) technology has had an enormous impact on
modern vaccinology. In order to optimize the efficacy and safety of VLP-based vaccines …

Vaccination with the pre-erythrocytic malaria vaccine RTS, S induces high levels of
antibodies and CD4+ T cells specific for the circumsporozoite protein (CSP). Using a …

Worldwide strategies between 2010 and 2017 aimed at controlling malarial parasites
(mainly Plasmodium falciparum) led to a reduction of just 18% regarding disease incidence …

Malignant tumors represent some of the most intractable diseases that endanger human
health. A glioma is a tumor of the central nervous system that is characterized by severe …