Alternative splicing is a substantial contributor to the high complexity of transcriptomes of
multicellular eukaryotes. In this Review, we discuss the accumulated evidence that most of …

Abstract RNA polymerase II (RNA Pol II) speed or elongation rate, ie, the number of
nucleotides synthesized per unit of time, is a major determinant of transcriptome …

The finding that small non-coding RNAs (ncRNAs) are able to control gene expression in a
sequence specific manner has had a massive impact on biology. Recent improvements in …

Precursor messenger RNA (pre-mRNA) splicing is a critical step in the posttranscriptional
regulation of gene expression, providing significant expansion of the functional proteome of …

Discoveries over the past decade portend a paradigm shift in molecular biology. Evidence
suggests that RNA is not only functional as a messenger between DNA and protein but also …

Somaclonal variation arises in plants and animals when differentiated somatic cells are
induced into a pluripotent state, but the resulting clones differ from each other and from their …

Although DNA methylation was originally thought to only affect transcription, emerging
evidence shows that it also regulates alternative splicing. Exons, and especially splice sites …

Small-RNA-guided gene regulation has emerged as one of the fundamental principles in
cell function, and the major protein players in this process are members of the Argonaute …

Massive high-throughput sequencing techniques allowed the identification of thousands of
noncoding RNAs (ncRNAs) and a plethora of different mRNA processing events occurring in …

Alternative splicing (AS) of precursor mRNAs (pre-mRNAs) from multiexon genes allows
organisms to increase their coding potential and regulate gene expression through multiple …