Apoptosis or programmed cell death is natural way of removing aged cells from the body.
Most of the anti-cancer therapies trigger apoptosis induction and related cell death networks …

Throughout their lifetimes, messenger RNAs (mRNAs) associate with proteins to form
ribonucleoproteins (mRNPs). Since the discovery of the first mRNP component more than 40 …

Although protein synthesis dynamics has been studied both with theoretical models and by
profiling ribosome footprints, the determinants of ribosome flux along open reading frames …

RNase H1-dependent antisense oligonucleotides (ASOs) are active in reducing levels of
both cytoplasmic mRNAs and nuclear retained RNAs. Although ASO activity in the nucleus …

Summary mRNA is thought to predominantly reside in the cytoplasm, where it is translated
and eventually degraded. Although nuclear retention of mRNA has a regulatory potential, it …

A large number of mutations in genes that encode RNA binding proteins cause human
disease. Many of these RNA binding proteins mediate key steps in post-transcriptional …

Nuclear pore complexes (NPCs) are indispensable for cell function and are at the center of
several human diseases. NPCs provide access to the nucleus and regulate the transport of …

Nuclear export of mRNAs is a crucial step in the regulation of gene expression, linking
transcription in the nucleus to translation in the cytoplasm. Although important components …

The nuclear pore complex (NPC) is the massive protein assembly that regulates the
transport of macromolecules between the nucleus and the cytoplasm. Recent breakthroughs …

The polyadenosine tail (poly [A]-tail) is a universal modification of eukaryotic messenger
RNAs (mRNAs) and non-coding RNAs (ncRNAs). In budding yeast, Pap1-synthesized …