Therapeutic targets and interventional strategies in COVID-19: mechanisms and clinical studies

YW Zhou, Y Xie, LS Tang, D Pu, YJ Zhu… - Signal transduction and …, 2021 - nature.com
Owing to the limitations of the present efforts on drug discovery against severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) and the lack of the understanding of the …

[HTML][HTML] The central role of the nasal microenvironment in the transmission, modulation, and clinical progression of SARS-CoV-2 infection

O Gallo, LG Locatello, A Mazzoni, L Novelli… - Mucosal …, 2021 - Elsevier
The novel coronavirus SARS-CoV-2 enters into the human body mainly through the ACE2+
TMPRSS2+ nasal epithelial cells. The initial host response to this pathogen occurs in a …

First-dose mRNA vaccination is sufficient to reactivate immunological memory to SARS-CoV-2 in subjects who have recovered from COVID-19

A Mazzoni, N Di Lauria, L Maggi… - The Journal of …, 2021 - Am Soc Clin Investig
The characterization of the adaptive immune response to COVID-19 vaccination in
individuals who recovered from SARS-CoV-2 infection may define current and future clinical …

Characterization of SARS-CoV-2-specific humoral immunity and its potential applications and therapeutic prospects

J Zheng, Y Deng, Z Zhao, B Mao, M Lu, Y Lin… - Cellular & molecular …, 2022 - nature.com
Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), is an ongoing pandemic that poses a great threat to …

Impact of aging on immunity in the context of COVID-19, HIV, and tuberculosis

A Grifoni, T Alonzi, G Alter, DMC Noonan… - Frontiers in …, 2023 - frontiersin.org
Knowledge of aging biology needs to be expanded due to the continuously growing number
of elderly people worldwide. Aging induces changes that affect all systems of the body. The …

Guidelines for the use of flow cytometry and cell sorting in immunological studies

A Cossarizza, HD Chang, A Radbruch… - European journal of …, 2021 - Wiley Online Library
The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …

[HTML][HTML] A third booster dose may be necessary to mitigate neutralizing antibody fading after inoculation with two doses of an inactivated SARS‐CoV‐2 vaccine

L Yue, T Xie, T Yang, J Zhou, H Chen… - Journal of medical …, 2022 - ncbi.nlm.nih.gov
To The Editor, Since the outbreak at the end of 2019, coronavirus disease 2019 (COVID‐
19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) …

SARS-CoV-2 infection and vaccination trigger long-lived B and CD4+ T lymphocytes with implications for booster strategies

A Mazzoni, A Vanni, M Spinicci… - The Journal of …, 2022 - Am Soc Clin Investig
BACKGROUND Immunization against SARS-CoV-2, the causative agent of COVID-19,
occurs via natural infection or vaccination. However, it is currently unknown how long …

Immune responses in mildly versus critically ill COVID-19 patients

H Nasrollahi, AG Talepoor, Z Saleh… - Frontiers in …, 2023 - frontiersin.org
The current coronavirus pandemic (COVID-19), caused by SARS-CoV-2, has had
devastating effects on the global health and economic system. The cellular and molecular …

Hallmarks of immune response in COVID-19: Exploring dysregulation and exhaustion

A Mazzoni, L Salvati, L Maggi, F Annunziato… - Seminars in …, 2021 - Elsevier
One and half year following the occurrence of COVID-19 pandemic, significant efforts from
laboratories all over the world generated a huge amount of data describing the prototypical …