Significance: Optical imaging using the endogenous fluorescence of metabolic cofactors has
enabled nondestructive examination of dynamic changes in cell and tissue function both in …

Patient-derived cancer organoids (PDCOs) are organotypic 3D cultures grown from patient
tumor samples. PDCOs provide an exciting opportunity to study drug response and …

New tools are needed to match cancer patients with effective treatments. Patient-derived
organoids offer a high-throughput platform to personalize treatments and discover novel …

Label-free imaging through two-photon autofluorescence of NAD (P) H allows for
nondestructive, high-resolution visualization of cellular activities in living systems. However …

Abstract While NAD (P) H fluorescence lifetime imaging (FLIM) can detect changes in flux
through the TCA cycle and electron transport chain (ETC), it remains unclear whether NAD …

Toxoplasma gondii, the causative agent of toxoplasmosis, is an obligate intracellular
parasite that infects warm-blooded vertebrates across the world. In humans, seropositivity …

Many experimental models demonstrated that inorganic and organic selenium (Se)
compounds may have an anticancer activity. However, large clinical studies failed to …

Chronic wounds are difficult to diagnose and characterize due to a lack of quantitative
biomarkers. Label-free multiphoton microscopy has emerged as a useful imaging modality …

Intratumoral heterogeneity, which is manifested in almost all of the hallmarks of cancer,
including the significantly altered metabolic profiles of cancer cells, represents a challenge …

The paper proposes an innovative deep convolutional neural network (DCNN) combined
with texture map for detecting cancerous regions and marking the ROI in a single model …