IGF-binding proteins secreted by cancer-associated fibroblasts induce context-dependent drug sensitization of lung cancer cells
Cancer-associated fibroblasts (CAFs) in the tumor microenvironment are often linked to drug
resistance. Here, we found that coculture with CAFs or culture in CAF-conditioned medium …
resistance. Here, we found that coculture with CAFs or culture in CAF-conditioned medium …
[HTML][HTML] Functional roles and clinical values of insulin-like growth factor-binding protein-5 in different types of cancers
G Güllü, S Karabulut, M Akkiprik - Chinese journal of cancer, 2012 - ncbi.nlm.nih.gov
Insulin-like growth factor-binding proteins (IGFBPs) are critical regulators of the mitogenic
activity of insulin-like growth factors (IGFs). IGFBP5, one of these IGFBPs, has special …
activity of insulin-like growth factors (IGFs). IGFBP5, one of these IGFBPs, has special …
The renin–angiotensin system in the breast and breast cancer
GP Vinson, S Barker… - Endocrine-related cancer, 2012 - erc.bioscientifica.com
The successful use of high-dose synthetic estrogens to treat postmenopausal metastatic
breast cancer is the first effective 'chemical therapy'proven in clinical trial to treat any cancer …
breast cancer is the first effective 'chemical therapy'proven in clinical trial to treat any cancer …
[HTML][HTML] MicroRNA-140-5p inhibits the progression of colorectal cancer by targeting VEGFA
W Zhang, C Zou, L Pan, Y Xu, W Qi, G Ma… - Cellular Physiology and …, 2015 - karger.com
Background: microRNAs (miRNAs) are small non-coding RNAs and have been shown to
play a crucial role in the colorectal cancer (CRC) tumorigenesis and progression. The aim of …
play a crucial role in the colorectal cancer (CRC) tumorigenesis and progression. The aim of …
MicroRNA profiling predicts survival in anti-EGFR treated chemorefractory metastatic colorectal cancer patients with wild-type KRAS and BRAF
N Mosakhani, L Lahti, I Borze… - Cancer genetics, 2012 - Elsevier
Anti-EGFR monoclonal antibodies (anti-EGFRmAb) serve in the treatment of metastatic
colorectal cancer (mCRC), but patients with a mutation in KRAS/BRAF and nearly one-half …
colorectal cancer (mCRC), but patients with a mutation in KRAS/BRAF and nearly one-half …
PKNOX2 suppresses gastric cancer through the transcriptional activation of IGFBP5 and p53
Promoter methylation plays a vital role in tumorigenesis through transcriptional silencing of
tumor suppressive genes. Using genome-wide methylation array, we first identified …
tumor suppressive genes. Using genome-wide methylation array, we first identified …
Potentially novel candidate biomarkers for head and neck squamous cell carcinoma identified using an integrated cell line-based discovery strategy
L Sepiashvili, A Hui, V Ignatchenko, W Shi, S Su… - Molecular & Cellular …, 2012 - ASBMB
Head and neck squamous cell carcinomas (HNSCC) can arise from the oral cavity,
oropharynx, larynx or hypopharynx, and is the sixth leading cancer by incidence worldwide …
oropharynx, larynx or hypopharynx, and is the sixth leading cancer by incidence worldwide …
A new role for the mitochondrial pro-apoptotic protein SMAC/Diablo in phospholipid synthesis associated with tumorigenesis
The mitochondrial pro-apoptotic protein SMAC/Diablo participates in apoptosis by
negatively regulating IAPs and activating caspases, thus encouraging apoptosis …
negatively regulating IAPs and activating caspases, thus encouraging apoptosis …
Evaluation of the impact of cachexia on clinical outcomes in aggressive lymphoma
Cancer cachexia is a state of involuntary weight loss and altered body composition triggered
by an underlying malignancy. We sought to correlate measures of cachexia with clinical …
by an underlying malignancy. We sought to correlate measures of cachexia with clinical …
Understanding the key to targeting the IGF axis in cancer: a biomarker assessment
KA Lodhia, P Tienchaiananda, P Haluska - Frontiers in oncology, 2015 - frontiersin.org
Type 1 insulin like growth factor receptor (IGF-1R) targeted therapies showed compelling
pre-clinical evidence; however, to date, this has failed to translate into patient benefit in …
pre-clinical evidence; however, to date, this has failed to translate into patient benefit in …