Pathogen diversity, immunity, and the fate of infections: lessons learned from Trypanosoma cruzi human–host interactions

LMD Magalhães, KJ Gollob, B Zingales… - The Lancet …, 2022 - thelancet.com
The complexity of host–pathogen interactions often leads to distinct clinical outcomes upon
infection with different pathogen strains. In this Review, we explore the interactions between …

Superantigens, a paradox of the immune response

S Noli Truant, DM Redolfi, MB Sarratea, EL Malchiodi… - Toxins, 2022 - mdpi.com
Staphylococcal enterotoxins are a wide family of bacterial exotoxins with the capacity to
activate as much as 20% of the host T cells, which is why they were called superantigens …

The case for the development of a Chagas disease vaccine: why? How? When?

E Dumonteil, C Herrera - Tropical Medicine and Infectious Disease, 2021 - mdpi.com
Chagas disease is a major neglected tropical disease, transmitted predominantly by
triatomine insect vectors, but also through congenital and oral routes. While endemic in the …

Development of chimeric protein as a multivalent vaccine for human Kinetoplastid infections: Chagas disease and leishmaniasis

M de Carvalho Clímaco, LA de Figueiredo, RC Lucas… - Vaccine, 2023 - Elsevier
Leishmania spp. and Trypanosoma cruzi are parasitic kinetoplastids of great medical and
epidemiological importance since they are responsible for thousands of deaths and …

Challenges and advancements in the development of vaccines and therapies against Chagas disease

MJ Pinazo, E Malchiodi, JR Ioset, A Bivona… - The Lancet …, 2024 - thelancet.com
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, presents a
substantial global health burden, affecting millions of individuals worldwide and posing a …

Immune system disorders: from molecular mechanisms to clinical implications

MM Fernandez, RD Motrich, M Ostrowski… - Frontiers in …, 2024 - frontiersin.org
In recent years, our understanding of the immune system has expanded significantly,
highlighting its crucial role not only in the defense against pathogens, toxins and tumor cells …

clinical implications

MM Fernandez¹, RD Motrich, M Ostrowski… - … to clinical implications, 2024 - books.google.com
In recent years, our understanding of the immune system has expanded significantly,
highlighting its crucial role not only in the defense against pathogens, toxins and tumor cells …

[PDF][PDF] Benoit Stijlemans1, 2, Boyoon Choi3, Andres Álvarez-Rodríguez1, 4

B Jin, M Radwanska, S Magez - 2024 - researchgate.net
Parasites within the Trypanosoma genus are flagellated eukaryote kinetoplast protozoans,
mostly transmitted by an insect vector. The occurrence of sexual reproduction of …

The Streptococcus pyogenes hyaluronic acid capsule prevents neutrophil clearance, and greater insights into the streptococcal M protein as a vaccine candidate and …

J Hurst - 2022 - search.proquest.com
Streptococcus pyogenes is a human-specific opportunistic pathogen that exploits an
assortment of surface molecules to overcome host clearing mechanisms and cause a …

The Case for the Development of a Chagas Disease Vaccine: Why? How? When?

C Herrera - Tropical Medicine and Infectious Disease, 2021 - search.proquest.com
Chagas disease is a major neglected tropical disease, transmitted predominantly by
triatomine insect vectors, but also through congenital and oral routes. While endemic in the …