While the processing of mRNA is essential for gene expression, recent findings have
highlighted that RNA processing is systematically altered in cancer. Mutations in RNA …

Altered gene expression is the primary molecular mechanism responsible for the
pathological processes of human diseases, including cancer. MicroRNAs (miRNAs) are …

Many primary-tumor subregions have low levels of molecular oxygen, termed hypoxia.
Hypoxic tumors are at elevated risk for local failure and distant metastasis, but the molecular …

While oxygen is critical to the continued existence of complex organisms, extreme levels of
oxygen within a system, known as hypoxia (low levels of oxygen) and hyperoxia (excessive …

We report a comprehensive molecular characterization of pheochromocytomas and
paragangliomas (PCCs/PGLs), a rare tumor type. Multi-platform integration revealed that …

Abstract miRNAs are a key component of the noncoding RNA family. The underlying
mechanisms involved in the interplay between the tumor microenvironment and cancer cells …

Research in many cancers has uncovered changes in metabolic pathways that control
tumour energetics and biosynthesis, so-called metabolic reprogramming. Studies in clear …

Hypoxia is an essential hallmark of several serious diseases such as cardiovascular and
metabolic disorders and cancer. A decline in the tissue oxygen level induces hypoxic …

Angiogenesis is involved in maintaining normal physiological processes like embryonic
development, wound healing, inflammation and reproduction. Pathogenesis of various …

The decline of oxygen tension in the tissues below the physiological demand leads to the
hypoxic adaptive response. This physiological consequence enables cells to recover from …