Oral delivery of peptide and protein drugs faces immense challenge partially due to the
gastrointestinal (GI) environment. In spite of considerable efforts by industrial and academic …

Biological cell membranes are a natural barrier for living cells. In the last few decades, the
cell membrane has been the main hurdle in the efficient delivery of bioactive and therapeutic …

Adsorptive-mediated transcytosis (AMT) provides a means for brain delivery of medicines
across the blood-brain barrier (BBB). The BBB is readily equipped for the AMT process: it …

Oligonucleotide-based drugs have received considerable attention for their capacity to
modulate gene expression very specifically and as a consequence they have found …

Oral delivery of peptides and proteins remains an attractive alternative to parenteral delivery
and has challenged various attempts at delivery development. Incorporation of new tools …

Non-viral gene delivery is currently a hot subject for its relative safety and simplicity of use;
however, it is still far from being ideal enough to be clinically used for its comparatively lower …

Highlights•Cell-penetrating peptides (CPPs) as a potential strategy to deliver drugs.•Biology,
classification and mechanisms of internalization of CPPs.•HIV-derived Tat peptide (pTat) as …

The potential use of antisense and siRNA oligonucleotides as therapeutic agents has
elicited a great deal of interest. However, a major issue for oligonucleotide-based …

Cell penetrating peptides, generally categorized as amphipathic or cationic depending on
their sequence, are increasingly drawing attention as a non-invasive delivery technology for …

Objectives The chronic and progressive nature of diabetes is usually associated with micro-
and macrovascular complications where failure of pancreatic β-cell function and a general …