Biomarkers of aging

Aging Biomarker Consortium, H Bao, J Cao… - Science China Life …, 2023 - Springer
Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

Cell non-autonomous regulation of cerebrovascular aging processes by the somatotropic axis

MA Bickel, B Csik, R Gulej, A Ungvari… - Frontiers in …, 2023 - frontiersin.org
Age-related cerebrovascular pathologies, ranging from cerebromicrovascular functional and
structural alterations to large vessel atherosclerosis, promote the genesis of vascular …

Correlation between white matter hyperintensities related gray matter volume and cognition in cerebral small vessel disease

Y Wang, Y Yang, T Wang, S Nie, H Yin, J Liu - Journal of Stroke and …, 2020 - Elsevier
Abstract Background and Aim The relationship between severity of cerebral small vessel
disease, as defined by white matter hyperintensities classification, and gray matter volume of …

[HTML][HTML] White matter changes underlie hypertension-related cognitive decline in older adults

Z Li, W Wang, F Sang, Z Zhang, X Li - NeuroImage: Clinical, 2023 - Elsevier
Hypertension has been well recognized as a risk factor for cognitive impairment and
dementia. Although the underlying mechanisms of hypertension-affected cognitive …

Predicting the severity of white matter lesions among patients with cerebrovascular risk factors based on retinal images and clinical laboratory data: A deep learning …

L Shu, K Zhong, N Chen, W Gu, W Shang… - Frontiers in …, 2023 - frontiersin.org
Background and purpose As one common feature of cerebral small vascular disease
(cSVD), white matter lesions (WMLs) could lead to reduction in brain function. Using a …

Disentangling in-vivo microstructural changes of white and gray matter in mild cognitive impairment and Alzheimer's disease: A systematic review and meta-analysis

S Zhong, J Lou, K Ma, Z Shu, L Chen, C Li, Q Ye… - Brain Imaging and …, 2023 - Springer
The microstructural characteristics of white and gray matter in mild cognitive impairment
(MCI) and the early-stage of Alzheimer's disease (AD) remain unclear. This study aimed to …

White matter fractional anisotropy is a superior predictor for cognitive impairment than brain volumes in older adults with confluent white matter hyperintensities

Y Xing, J Yang, A Zhou, F Wang, C Wei, Y Tang… - Frontiers in …, 2021 - frontiersin.org
Older patients with confluent white matter hyperintensities (WMHs) on magnetic resonance
imaging have an increased risk for the onset of vascular cognitive impairment (VCI). This …

Impact of white matter hyperintensities on structural connectivity and cognition in cognitively intact ADNI participants

M Taghvaei, DJ Mechanic-Hamilton, S Sadaghiani… - Neurobiology of …, 2024 - Elsevier
We used indirect brain mapping with virtual lesion tractography to test the hypothesis that
the extent of white matter tract disconnection due to white matter hyperintensities (WMH) is …

Altered dynamic functional network connectivity and topological organization variance in patients with white matter hyperintensities

C Huang, X Zhou, M Ren, W Zhang… - Journal of …, 2023 - Wiley Online Library
White matter hyperintensities (WMHs) of presumed vascular origin are important imaging
biomarkers of cerebral small vessel disease (CSVD). Previous studies have verified …

[HTML][HTML] Development and validation of a multimodal deep learning framework for vascular cognitive impairment diagnosis

F Fan, H Song, J Jiang, H He, D Sun, Z Xu, S Peng… - Iscience, 2024 - cell.com
Cerebrovascular disease (CVD) is the second leading cause of dementia worldwide. The
accurate detection of vascular cognitive impairment (VCI) in CVD patients remains an …