Amyotrophic lateral sclerosis is a fatal CNS neurodegenerative disease. Despite intensive
research, current management of amyotrophic lateral sclerosis remains suboptimal from …

Inclusions of pathogenic deposits containing TAR DNA-binding protein 43 (TDP-43) are
evident in the brain and spinal cord of patients that present across a spectrum of …

1. Background The El Escorial criteria for the diagnosis of Amyotrophic Lateral Sclerosis
(ALS) were initially published in 1994 (Brooks, 1994) and revised in 2000 (Brooks et al …

Objective The diagnosis of amyotrophic lateral sclerosis (ALS) remains problematic, with
current diagnostic criteria (revised El Escorial [rEEC] and Awaji) being complex and prone to …

Increasing appreciation of the phenotypic and biological overlap between amyotrophic
lateral sclerosis (ALS) and frontotemporal dementia, alongside evolving biomarker evidence …

The spinal cord is a conduit within the central nervous system (CNS) that provides ongoing
communication between the brain and the rest of the body, conveying complex sensory and …

The Sonic hedgehog (SHH) pathway affects neurogenesis and neural patterning during the
development of the central nervous system. Dysregulation of the SHH pathway in the brain …

Although the past two decades have produced exciting discoveries in the genetics and
pathology of amyotrophic lateral sclerosis (ALS), progress in developing an effective therapy …

Motor neuron disease is an umbrella term encompassing a multitude of clinically
heterogeneous phenotypes. The early and accurate categorisation of patients is hugely …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
loss of upper and lower motor neurons, resulting in progressive weakness of all voluntary …