Amyloid cardiomyopathy should be suspected in any patient who presents with heart failure
and preserved ejection fraction. In patients with echocardiographic evidence of ventricular …

Background: The p. Val142Ile variant, predominantly found among people of African
descent, is the most common cause of variant transthyretin amyloidosis and carriers …

Objective To assess the natural history and treatment effect on survival among patients with
transthyretin-associated familial amyloid polyneuropathy (TTR-FAP) stage 1 Val30Met …

Importance Individual cohort studies concur that the amyloidogenic V142I variant of the
transthyretin (TTR) gene, present in 3% to 4% of US Black individuals, increases heart …

Transthyretin-related cardiac amyloidosis is a progressive infiltrative cardiomyopathy that
mimics hypertensive and hypertrophic heart disease and often goes undiagnosed. In the …

Abstract Introduction Hereditary transthyretin (ATTRv) amyloidosis is of autosomal dominant
transmission, caused by a spectrum of mutations in the transthyretin (TTR) gene. The …

Transthyretin amyloidosis (ATTR amyloidosis) is a rare disease characterised by
extracellular deposition of amyloid fibrils composed by transthyretin. ATTR amyloidosis can …

Background Transthyretin amyloid cardiomyopathy (ATTR‐CM) is an important cause of
heart failure in older individuals. Misfolding and deposition of transthyretin or prealbumin …

Abstract Background Transthyretin (TTR) pV 142I (rs76992529‐A) is one of the 113 variants
in the human TTR gene associated with systemic amyloidosis. It results from a G to A …

Heritable cardiac amyloidosis (CA) is an underrecognized cause of morbidity and mortality
in the USA. It results from the accumulation of the misfolded protein transthyretin within the …