[HTML][HTML] Advancing Treatment Options for Merkel Cell Carcinoma: A Review of Tumor-Targeted Therapies

HM Nammour, K Madrigal, CT Starling… - International journal of …, 2024 - mdpi.com
Although rare, Merkel cell carcinoma (MCC) is a highly aggressive and increasingly
prevalent neuroendocrine cancer of the skin. While current interventions, including surgical …

Inhibition of PI3K by copanlisib exerts potent antitumor effects on Merkel cell carcinoma cell lines and mouse xenografts

B Fang, A Kannan, S Zhao, QH Nguyen, S Ejadi… - Scientific reports, 2020 - nature.com
Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine skin cancer with
steadily increasing incidence and poor prognosis. Despite recent success with …

Navitoclax combined with Alpelisib effectively inhibits Merkel cell carcinoma cell growth in vitro

E Chteinberg, S Wetzels, W Gerritsen… - … in medical oncology, 2020 - journals.sagepub.com
Background: Merkel cell carcinoma (MCC) is a highly malignant skin cancer. Despite major
treatment improvements during the last decade, up to 50% of patients do not respond to …

Therapeutic potential of 5′-methylschweinfurthin G in Merkel cell polyomavirus-positive Merkel cell carcinoma

EJ Koubek, JS Weissenrieder, LE Ortiz, N Nwogu… - Viruses, 2022 - mdpi.com
Merkel cell carcinoma (MCC) is a rare but aggressive form of skin cancer predominantly
caused by the human Merkel cell polyomavirus (MCPyV). Treatment for MCC includes …

Molecular and immune targets for Merkel cell carcinoma therapy and prevention

L Cohen, KY Tsai - Molecular Carcinogenesis, 2019 - Wiley Online Library
Merkel cell carcinoma (MCC) is a rare neuroendocrine carcinoma of the skin, for which the
exact mechanisms of carcinogenesis remain unknown. Therapeutic options for this highly …

Merkel cell polyomavirus and human Merkel cell carcinoma

W Liu, J You - Viruses and Human Cancer: From Basic Science to …, 2021 - Springer
Merkel cell polyomavirus (MCPyV) is the most recently discovered human oncogenic virus.
MCPyV asymptomatically infects most of the human population. In the elderly and …