The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune
functions and serves as a pivotal mediator of inflammatory response. In the first part of this …

Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a
high morbidity additionally, CRC patients may develop liver metastasis, which is the major …

Over the course of past few years, cancer immunotherapy has been accompanied with
promising results. However, preliminary investigations with respect to immunotherapy …

Immunotherapy with checkpoint inhibitors is well established as an effective treatment for
non-small cell lung cancer and melanoma. The list of approved indications for treatment with …

The development of immune checkpoint inhibitors [monoclonal antibodies targeting
cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), programmed cell death protein 1 (PD …

Autoimmune hepatitis (AIH) is a severe liver disease that affects children and adults
worldwide. The diagnosis of AIH relies on increased serum transaminase and …

Programmed cell death 1 receptor (PD-1) and its ligands constitute an inhibitory pathway to
mediate the mechanism of immune tolerance and provide immune homeostasis …

Allergic asthma is a leading chronic disease associated with airway hyperreactivity (AHR).
Type-2 innate lymphoid cells (ILC2s) are a potent source of T-helper 2 (Th2) cytokines that …

Three important factors, including genetics, environment factors and autoimmunity play a
role in the pathogenesis of rheumatoid arthritis (RA). The heritability of RA has been …

Colorectal cancer (CRC) has the second highest mortality rate among all cancers
worldwide. Surgery, chemotherapy, radiotherapy, molecular targeting and other treatment …