The endoplasmic reticulum (ER) functions as a quality-control organelle for protein
homeostasis, or “proteostasis”. The protein quality control systems involve ER-associated …

Retinitis pigmentosa (RP) is a heterogeneous group of hereditary diseases characterized by
progressive degeneration of retinal photoreceptors leading to progressive visual decline. It …

Background Recently, great efforts have been made to design protocols for obtaining ocular
cells from human stem cells to model diseases or for regenerative purposes. Current …

Retinal pigment epithelial (RPE) cell dysfunction and death are characteristics of age-
related macular degeneration. A promising therapeutic option is RPE cell transplantation …

The discovery of induced Pluripotent Stem)(iPS) cells has instigated innovation in various
fields, including ophthalmology. Cell therapy has shown tremendous progress in …

Purpose To assess the safety and feasibility of direct vitrectomy-sparing subretinal injection
for gene delivery in a large animal model. Methods The experimental Liběchov minipigs …

Tissue engineering (TE) is a field of science that combines biological, engineering, and
medical sciences and allows the development of disease models, drug development and …

Background/Objectives: Age-related macular degeneration (AMD) and retinitis pigmentosa
(RP) are leading causes of vision loss, with AMD affecting older populations and RP being a …

Clinical studies using suspensions or sheets of human pluripotent cell-derived retinal
pigment epithelial cells (hiPSC-RPE) have been conducted globally for diseases such as …

Retinal degeneration (RD) is a leading cause of blindness worldwide and includes
conditions such as retinitis pigmentosa (RP), age-related macular degeneration (AMD), and …