Although an immense knowledge has accumulated concerning regulation of cholesterol
homeostasis in the body, this does not include the brain, where details are just emerging …

Herpes simplex viruses types 1 and 2 (HSV1 and HSV2) and varicella-zoster virus (VZV)
establish latent infection in dorsal root ganglia for the entire life of the host. From this …

The molecular mechanisms controlling synaptogenesis in the central nervous system (CNS)
are poorly understood. Previous reports showed that a glia-derived factor strongly promotes …

Cholesterol is a multifacetted molecule. First, it serves as an essential membrane
component, as a cofactor for signaling molecules and as a precursor for steroid hormones; …

Aβ peptide is the major proteinateous component of the amyloid plaques found in the brains
of Alzheimer's disease (AD) patients and is regarded by many as the culprit of the disorder. It …

The apolipoprotein E (APOE) genotype is the major genetic risk factor for Alzheimer's
disease (AD). We have access to cerebrospinal fluid (CSF) and plasma APOE protein levels …

Brain function depends on the cooperation between highly specialized cells. Neurons
generate electrical signals and glial cells provide structural and metabolic support. Here, I …

There is growing evidence to support the hypothesis that statins may act as neuroprotectants
in several neuropathological conditions, including Alzheimer's disease. The mechanisms for …

The brain is lipid‐rich compared to other organs and although previous studies have
highlighted the importance of ATP‐binding cassette (ABC) transporters in the regulation of …

Mutations in ABCA1 cause the allelic disorders familial hypolipoproteinemia and Tangier
Disease. To identify where ABCA1 was likely to have a functional role, we determined the …