The kidney has a remarkable ability of repair after acute kidney injury (AKI). However, when
injury is severe or persistent, the repair is incomplete or maladaptive and may lead to …

Inflammation is usually analysed from the perspective of tissue-infiltrating leukocytes.
Microvascular endothelial cells at a site of inflammation are both active participants in and …

Excessive inflammation is becoming accepted as a critical factor in many human diseases,
including inflammatory and autoimmune disorders, neurodegenerative conditions, infection …

Observational studies of necrotic core progression identify intraplaque hemorrhage as a
critical factor in atherosclerotic plaque growth and destabilization. The rapid accumulation of …

Evidence has been gathered regarding the association between angiogenesis and
inflammation in pathological situations. These two phenomena have long been coupled …

Fibrotic disorders account for an increasing burden of disease-associated morbidity and
mortality worldwide. Although numerous risk factors have been recognized, the etiologies of …

Vascular calcification often occurs with advancing age, atherosclerosis, various metabolic
disorders such as diabetes mellitus and end-stage renal disease, or in rare genetic …

Injury of skeletal muscle, and especially mechanically induced damage such as contusion
injury, frequently occurs in contact sports, as well as in accidental contact sports, such as …

The multitude and abundance of macrophage-derived mediators in rheumatoid arthritis and
their paracrine/autocrine effects identify macrophages as local and systemic amplifiers of …

Aging is associated with hyporesponse to vaccination, whose mechanisms remain unclear.
In this study hepatitis B virus (HBV)-naive older adults received three vaccines, including …