Increased plasma non-esterified fatty acids (NEFAs) link obesity with insulin resistance and
type 2 diabetes mellitus (T2DM). However, in contrast to the saturated FA (SFA) palmitic …

Free fatty acids (FFAs) are important substrates for mitochondrial oxidative metabolism and
ATP synthesis but also cause serious stress to various tissues, contributing to the …

CD36 is a multiligand receptor contributing to glucose and lipid metabolism, immune
response, inflammation, thrombosis, and fibrosis. A wide range of tissue expression includes …

The cluster of differentiation 36 (CD36) is a scavenger receptor present on various types of
cells and has multiple biological functions that may be important in inflammation and in the …

Caloric restriction is a popular approach to treat obesity and its associated chronic illnesses
but is difficult to maintain for a long time. Intermittent fasting is an alternative and easily …

Aim/hypothesis Cluster determinant 36 (CD36), a fatty acid transporter, was reported to have
a pivotal role in glucotoxicity-induced beta cell dysfunction. However, little is known about …

In type 2 diabetes, metabolic stress has a negative impact on pancreatic β-cell function and
survival (T2D). Although the pathogenesis of metabolic stress is complex, an imbalance in …

Lipotoxicity is a major contributor to type 2 diabetes mainly promoting mitochondrial
dysfunction. Lipotoxic stress is mediated by elevated levels of free fatty acids through …

We recently reported that cluster determinant 36 (CD36), a fatty acid transporter, plays a
pivotal role in glucotoxicity-induced β-cell dysfunction. However, little is known about how …

Obesity and type 2 diabetes (T2D) are growing health problems associated with a loss of
insulin sensitivity. Both conditions arise from a long-term energy imbalance, and frequently …