Abstract 'Autophagy'refers to an evolutionarily conserved process through which cellular
contents, such as damaged organelles and protein aggregates, are delivered to lysosomes …

Glutamate is the most commonly engaged neurotransmitter in the mammalian central
nervous system, acting to mediate excitatory neurotransmission. However, high levels of …

In recent years, accumulating evidence has elucidated the role of lysosomes in dynamically
regulating cellular and organismal homeostasis. Lysosomal changes and dysfunction have …

In recent years, rapid discoveries have been made relating to Ca 2+ handling at specific
organelles that have important implications for whole-cell Ca 2+ homeostasis. In particular …

Genetic variation around the LRRK2 gene affects risk of both familial and sporadic
Parkinson's disease (PD). However, the biological functions of LRRK2 remain incompletely …

The endoplasmic reticulum (ER), mitochondria and lysosomes are physically and/or
functionally linked, establishing close contact sites between these organelles. As a …

Since the discovery of leucine-rich repeat kinase 2 (LRRK2) as a protein that is likely central
to the aetiology of Parkinson's disease, a considerable amount of work has gone into …

Glucocerebrosidase (GBA1) gene mutations increase the risk of Parkinson disease (PD).
While the cellular mechanisms associating GBA1 mutations and PD are unknown, loss of …

Mutations in the leucine-rich-repeat kinase 2 (LRRK2) gene are associated with familial and
sporadic cases of Parkinson's disease but are also found in immune-related disorders such …

Parkinson disease (PD) is a neurodegenerative disorder pathologically characterized by
nigrostriatal dopamine neuron loss and the postmortem presence of Lewy bodies …