Enzymes are complex biological catalysts and are critical to life. Most oxidations of
chemicals are catalyzed by cytochrome P450 (P450, CYP) enzymes, which generally utilize …

Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …

Cytochrome P450 (CYP450) enzymes belong to a superfamily of heme-containing proteins
that are involved in the metabolism of structurally diverse endogenous and exogenous …

Metoclopramide is a widely used clinical drug in a variety of medical settings with rare acute
dystonic events reported. The aim of this study was to assess a previous report of …

Abstract Motivation: Cytochrome P450 (CYP) is a superfamily of enzymes responsible for the
metabolism of drugs, xenobiotics and endogenous compounds. CYP2D6 metabolizes about …

Nitidine chloride (NC) is a benzophenanthridine alkaloid isolated from the roots of
Zanthoxylum nitidum (Roxb.) DC, a widely used traditional herbal medicine. Several reports …

Cytochromes are proteins that catalyze electron transfer reactions of well-known metabolic
pathways and are classified in various superfamilies. The CYP, or P450, superfamily …

Cytochrome P450 enzymes (CYPs) represent an important enzyme superfamily involved in
metabolism of many endogenous and exogenous small molecules. CYP2D6 is responsible …

Dacomitinib is currently in development for the treatment of non‐small cell lung cancer.
Formation of the major circulating metabolite (PF‐05199265) is mediated by cytochrome …

Okanin, a major flavonoid of a popular herb tea, Coreopsis tinctoria Nutt., showed strong
inhibition on CYP3A4 and CYP2D6. The strong interaction between okanin and CYPs were …