It is widely accepted that senescent cells accumulate with aging. They are characterized by
replicative arrest and the release of a myriad of factors commonly called the senescence …

Proteins from the Polycomb group (PcG) are epigenetic chromatin modifiers involved in
cancer development and also in the maintenance of embryonic and adult stem cells. The …

Reversal of promoter DNA hypermethylation and associated gene silencing is an attractive
cancer therapy approach. The DNA methylation inhibitors decitabine and azacitidine are …

The Ink4a/Arf locus encodes 2 tumor suppressor molecules, p16INK4a and Arf, which are
principal mediators of cellular senescence. To study the links between senescence and …

Mammalian aging occurs in part because of a decline in the restorative capacity of tissue
stem cells. These self-renewing cells are rendered malignant by a small number of …

Cellular senescence, first observed and defined using in vitro cell culture studies, is an
irreversible cell cycle arrest which can be triggered by a variety of factors. Emerging …

Many physiological processes, including proper tissue development and homeostasis,
require a balance between apoptosis and cell proliferation. All somatic cells proliferate via a …

Over the last decade, a growing number of tumor suppressor genes have been discovered
to play a role in tumorigenesis. Mutations of p53 have been found in hematological …

Exposure to total body irradiation (TBI) induces not only acute hematopoietic radiation
syndrome but also long-term or residual bone marrow (BM) injury. This residual BM injury is …

Bone marrow (BM) suppression is an important dose-limiting side effect of chemotherapy
and radiotherapy for cancer. Although acute myelosuppression is an immediate concern for …