With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to …

Single-molecule FRET (smFRET) has become a mainstream technique for studying
biomolecular structural dynamics. The rapid and wide adoption of smFRET experiments by …

Proteins are structurally dynamic macromolecules, and it is challenging to quantify the
conformational properties of their native state in solution. Nanopores can be efficient tools to …

In eukaryotes, accurate protein synthesis relies on a family of translational GTPases that pair
with specific decoding factors to decipher the mRNA code on ribosomes. We present …

In all species, ribosomes synthesize proteins by faithfully decoding messenger RNA (mRNA)
nucleotide sequences using aminoacyl-tRNA substrates. Current knowledge of the …

During protein synthesis, the ribosome accurately selects transfer RNAs (tRNAs) in
accordance with the messenger RNA (mRNA) triplet in the decoding centre. tRNA selection …

Molecular dynamics simulations can now track rapid processes—those occurring in less
than about a millisecond—at atomic resolution for many biologically relevant systems. These …

The elongation cycle of protein synthesis involves the delivery of aminoacyl-transfer RNAs to
the aminoacyl-tRNA-binding site (A site) of the ribosome, followed by peptide-bond …

Macromolecular machines, such as the ribosome, undergo large-scale conformational
changes during their functional cycles. Although their mode of action is often compared to …

Molecular dynamics simulations with coarse-grained and/or simplified Hamiltonians are an
effective means of capturing the functionally important long-time and large-length scale …