During mammalian embryonic development, primary cilia transduce and regulate several
signaling pathways. Among the various pathways, Sonic hedgehog (SHH) is one of the most …

Thyroid hormones are important during development of the mammalian brain, acting on
migration and differentiation of neural cells, synaptogenesis, and myelination. The actions of …

Medulloblastoma (MB) comprises a group of heterogeneous paediatric embryonal
neoplasms of the hindbrain with strong links to early development of the hindbrain 1, 2, 3, 4 …

The human neonatal cerebellum is one-fourth of its adult size yet contains the blueprint
required to integrate environmental cues with developing motor, cognitive and emotional …

Study of the origin and development of cerebellar tumours has been hampered by the
complexity and heterogeneity of cerebellar cells that change over the course of …

Autophagic turnover of mitochondria, termed mitophagy, is proposed to be an essential
quality-control (QC) mechanism of pathophysiological relevance in mammals. However, if …

N 6-methyladenosine (m6A) RNA methylation is the most abundant modification on mRNAs
and plays important roles in various biological processes. The formation of m6A is catalyzed …

The cerebellum develops from a restricted number of cell types that precisely organize to
form the circuitry that controls sensory-motor coordination and some higher-order cognitive …

Granule cells (GCs) are the most numerous cell type in the cerebellum and indeed, in the
brain: at least 99% of all cerebellar neurons are granule cells. In this review article, we first …

Within the substantially different time scales characterizing human and rodent brain
development, key developmental processes are remarkably preserved. Shared processes …