Summary The interleukin‐1 (IL‐1) family of cytokines and receptors is unique in immunology
because the IL‐1 family and Toll‐like receptor (TLR) families share similar functions. More …

More than any other cytokine family, the 11 members of the IL-1 family are associated with
innate immune responses, which occur in acute inflammation and chronic inflammatory …

The extracellular forms of the IL‐1 cytokines are active through binding to specific receptors
on the surface of target cells. IL‐1 ligands bind to the extracellular portion of their ligand …

More than any other cytokine family, the interleukin (IL)-1 family is closely linked to the
innate immune response. This linkage became evident upon the discovery that the …

ABSTRACT IL-1 and its related family member IL-18 are primarily proinflammatory cytokines
by their ability to stimulate the expression of genes associated with inflammation and …

The IL-1 family of cytokines encompasses eleven proteins that each share a similar-barrel
structure and bind to Ig-like receptors. Some of the IL-1-like cytokines have been well …

The fourth edition of The Cytokine Handbook provides an encyclopedic coverage of the
molecules that induce and regulate immune responses. Now expanded to two volumes, co …

The activity of each member of the IL-1 family of ligands is mediated by its own receptor.
Each ligand binds specifically to the extracellular “ligand binding chain” containing three Ig …

IL-1 is of utmost importance in the host response to immunological challenges. We identified
and functionally characterized two novel IL-1 ligands termed IL-1δ and IL-1ε. Northern blot …

Interleukin-1 is a key inflammatory cytokine that mediates its effects through a type I receptor
and a receptor accessory protein. These two molecules are members of a wider family of …