Amyloid-β precursor protein (APP) is a membrane-spanning protein with a large
extracellular domain and a much smaller intracellular domain. It is the source of the amyloid …

This article serves as a primer for the theory of online meaning construction known
alternately as conceptual blending, conceptual integration, the many space model, and the …

beta-Amyloid precursor protein (beta-APP), the source of the fibrillogenic amyloid beta-
peptide (A beta) that accumulates in the brain of victims of Alzheimer's disease, is a …

The amyloid precursor protein (APP) plays a central role in the pathophysiology of
Alzheimer's disease in large part due to the sequential proteolytic cleavages that result in …

The amyloid precursor protein (APP) takes a central position in Alzheimer's disease (AD)
pathogenesis: APP processing generates the β-amyloid (Aβ) peptides, which are deposited …

Alzheimer's disease (AD) clinical trials, focused on disease modifying drugs and conducted
in patients with mild to moderate AD, as well as prodromal (early) AD, have failed to reach …

Background Alzheimer's disease (AD) involves increased accumulation of amyloid-β (Aβ)
plaques and neurofibrillary tangles as well as neuronal loss in various regions of the …

The amyloid precursor protein (APP) plays a central role in Alzheimer's disease, but its
physiological function and that of its mammalian paralogs, the amyloid precursor‐like …

The amyloid precursor protein (APP) plays a critical role in Alzheimer's disease (AD)
pathogenesis. APP is proteolytically cleaved by β-and γ-secretases to generate the amyloid …

purpose. Retinal ganglion cell (RGC) death in glaucoma involves apoptosis. Activation of
caspases and abnormal processing of amyloid precursor protein (APP) are important events …