Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune
response associated with immunological memory, provided they display sufficient …

The cytotoxic activity of myeloid cells is regulated by a balance of signals that are transmitted
through inhibitory and activating receptors. The Cluster of Differentiation 47 (CD47) protein …

Calreticulin (CALR) is an endoplasmic reticulum (ER)-resident protein involved in a
spectrum of cellular processes. In healthy cells, CALR operates as a chaperone and Ca2+ …

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

Immunogenicity depends on two key factors: antigenicity and adjuvanticity. The presence of
exogenous or mutated antigens explains why infected cells and malignant cells can initiate …

Immune checkpoint inhibitors, including those targeting CTLA‐4/B7 and the PD‐1/PD‐L1
inhibitory pathways, are now available for clinical use in cancer patients, with other …

Background CD47 is a widely expressed cellular receptor well known for its
immunoregulatory functions. By interacting with its ligands, including thrombospondin-1 …

CD47, or integrin-associated protein, is a cell surface ligand expressed in low levels by
nearly all cells of the body. It plays an integral role in various immune responses as well as …

Malignant tumors contain heterogeneous populations of cells in various states of
proliferation and differentiation. The presence of cancer stem or initiating cells is a well …

Purpose: There is a quest for novel noninvasive diagnostic markers for the detection of
breast cancer. The goal of this study is to identify circulating microRNA (miRNA) signatures …