Memory engrams: Recalling the past and imagining the future

SA Josselyn, S Tonegawa - Science, 2020 - science.org
BACKGROUND The idea that memory is stored as enduring changes in the brain dates
back at least to the time of Plato and Aristotle (circa 350 BCE), but its scientific articulation …

An update on memory reconsolidation updating

JLC Lee, K Nader, D Schiller - Trends in cognitive sciences, 2017 - cell.com
The reactivation of a stored memory in the brain can make the memory transiently labile.
During the time it takes for the memory to restabilize (reconsolidate) the memory can either …

Distinct neural circuits for the formation and retrieval of episodic memories

DS Roy, T Kitamura, T Okuyama, SK Ogawa, C Sun… - Cell, 2017 - cell.com
The formation and retrieval of a memory is thought to be accomplished by activation and
reactivation, respectively, of the memory-holding cells (engram cells) by a common set of …

GABAA Receptor Subtypes: Therapeutic Potential in Down Syndrome, Affective Disorders, Schizophrenia, and Autism

U Rudolph, H Möhler - Annual review of pharmacology and …, 2014 - annualreviews.org
The γ-aminobutyric acid (GABA) system plays a pivotal role in orchestrating the
synchronicity of local networks and the functional coupling of different brain regions. Here …

Spatial contextual recognition memory updating is modulated by dopamine release in the dorsal hippocampus from the locus coeruleus

DK Gálvez-Márquez… - Proceedings of the …, 2022 - National Acad Sciences
Detecting novelty is critical to consolidate declarative memories, such as spatial contextual
recognition memory. It has been shown that stored memories, when retrieved, are …

Consolidation and reconsolidation: two lives of memories?

S McKenzie, H Eichenbaum - Neuron, 2011 - cell.com
Most studies on memory consolidation consider the new information as if it were imposed on
a tabula rasa, but considerable evidence indicates that new memories must be interleaved …

Long‐term plasticity in the hippocampus: maintaining within and 'tagging'between synapses

MZ Bin Ibrahim, A Benoy, S Sajikumar - The FEBS journal, 2022 - Wiley Online Library
Synapses between neurons are malleable biochemical structures, strengthening and
diminishing over time dependent on the type of information they receive. This phenomenon …

Diverse therapeutic developments for post-traumatic stress disorder (PTSD) indicate common mechanisms of memory modulation

SB Raut, PA Marathe, L van Eijk, R Eri… - Pharmacology & …, 2022 - Elsevier
Post-traumatic stress disorder (PTSD), characterized by abnormally persistent and
distressing memories, is a chronic debilitating condition in need of new treatment options …

Updating memories—the role of prediction errors in memory reconsolidation

MTJ Exton-McGuinness, JLC Lee… - Behavioural brain research, 2015 - Elsevier
Memories are not static imprints of past experience, but rather are dynamic entities which
enable us to predict outcomes of future situations and inform appropriate behaviours. In …

The fate of memory: Reconsolidation and the case of Prediction Error

RS Fernández, MM Boccia, ME Pedreira - Neuroscience & Biobehavioral …, 2016 - Elsevier
The ability to make predictions based on stored information is a general coding strategy. A
Prediction-Error (PE) is a mismatch between expected and current events. It was proposed …