Ca2+ regulation of contraction in vertebrate striated muscle is exerted primarily through
effects on the thin filament, which regulate strong cross-bridge binding to actin. Structural …

▪ Abstract Striated muscle is an intricate, efficient, and precise machine that contains
complex interconnected cytoskeletal networks critical for its contractile activity. The …

The passive elasticity of muscle is largely governed by the I-band part of the giant muscle
protein titin,,,, a complex molecular spring composed of a series of individually folded …

Titin is a giant vertebrate striated muscle protein with critical importance for myofibril
elasticity and structural integrity. We show here that the complete sequence of the human …

Through the study of single molecules it has become possible to explain the function of
many of the complex molecular assemblies found in cells,,,,. The protein titin provides …

Extension of the I-band segment of titin gives rise to part of the diastolic force of cardiac
muscle. Previous studies of human cardiac titin transcripts suggested a series of differential …

Titin (also known as connectin) is a giant protein with a wide range of cellular functions,
including providing muscle cells with elasticity. Its physiological extension is largely derived …

Titin constitutes the third myofilament of cardiac muscle, with a single giant polypeptide
spanning from the Z disk to the M-band region of the sarcomere1 (Figure 1). The 1.0-MDa …

Myofibrillogenesis in striated muscles is a highly complex process that depends on the
coordinated assembly and integration of a large number of contractile, cytoskeletal, and …

This article considers specific treatment approaches and the role of etiological mechanisms
in terms of clinical feature characteristics of MTrPs: increased muscle tension, pain and …