Genome editing is the modification of genomic DNA at a specific target site in a wide variety
of cell types and organisms, including insertion, deletion and replacement of DNA, resulting …

CRISPR/Cas9 precision genome editing has revolutionized cancer treatment by introducing
specific alterations to the cancer genome. But the therapeutic potential of CRISPR/Cas9 is …

Genome editing of human induced pluripotent stem cells (hiPSCs) offers unprecedented
opportunities for in vitro disease modeling and personalized cell replacement therapy. The …

Cellular reprogramming of somatic cells to human pluripotent stem cells (iPSC) represents
an efficient tool for in vitro modeling of human brain diseases and provides an innovative …

Down syndrome (DS) is the most prevalent chromosomal disorder associated with a higher
incidence of pulmonary arterial hypertension (PAH). The dysfunction of vascular endothelial …

Human induced pluripotent stem cells (hiPSCs) represent an ideal in vitro platform to study
human genetics and biology. The recent advent of programmable nucleases makes also the …

In the decade since Yamanaka and colleagues described methods to reprogram somatic
cells into a pluripotent state, human induced pluripotent stem cells (hiPSCs) have …

To investigate long-term trends of animal use, the EU animal use statistics from the 15
countries that have been in the EU since 1995 plus respective data from Switzerland were …

The epilepsies and related disorders of brain circuitry present significant challenges
associated with the use of human cells to study disease mechanisms and develop new …

Chromosomal aberrations include translocations, deletions, duplications, inversions,
aneuploidies and complex rearrangements. They underlie genetic disease in roughly 15 …