SOX2 is a well-characterized pluripotent factor that is essential for stem cell self-renewal,
reprogramming, and homeostasis. The cellular levels of SOX2 are precisely regulated by a …

The generation of induced pluripotent stem cells (iPSCs) from somatic cells demonstrated
that adult mammalian cells can be reprogrammed to a pluripotent state by the enforced …

Recently, several studies using cultures of human embryos together with single-cell RNA-
seq analyses have revealed differences between humans and mice, necessitating the study …

Cancer cells rely on dysregulated gene expression. This establishes specific transcriptional
addictions that may be therapeutically exploited. Yet, the mechanisms that are ultimately …

Duchenne muscular dystrophy (DMD) is a severe muscle-degenerative disease caused by a
mutation in the dystrophin gene. Genetic correction of patient-derived induced pluripotent …

Cancer stem cells (CSCs) are proposed to drive tumor initiation and progression. Yet, our
understanding of the cellular and molecular mechanisms that underlie CSC properties is …

The generation of induced pluripotent stem cells (iPSCs) provides the opportunity to use
patient-specific somatic cells, which are a valuable source for disease modeling and drug …

Much attention has focussed on the conversion of human pluripotent stem cells (PSCs) to a
more naïve developmental status. Here we provide a method for resetting via transient …

Efficient differentiation of embryonic stem cells (ESCs) and induced pluripotent stem cells
(iPSCs) to a variety of lineages requires step-wise approaches replicating the key …

Autism spectrum disorders (ASD) are complex neurodevelopmental diseases in which
different combinations of genetic mutations may contribute to the phenotype. Using Rett …