Salivary glands produce and secrete saliva, which is essential for maintaining oral health
and overall health. Understanding both the unique structure and physiological function of …

Store-operated calcium channels (SOCs) are a major pathway for calcium signaling in
virtually all metozoan cells and serve a wide variety of functions ranging from gene …

Store-operated Ca2+ entry (SOCE) is a ubiquitous Ca2+ signaling pathway that is
evolutionarily conserved across eukaryotes. SOCE is triggered physiologically when the …

The ubiquitous Ca 2+ release-activated Ca 2+(CRAC) channel is crucial to many
physiological functions. Both gain and loss of CRAC function is linked to disease. While …

Store-operated calcium entry (SOCE) is a ubiquitous Ca 2+ entry pathway that is activated in
response to depletion of ER-Ca 2+ stores and critically controls the regulation of …

The interplay between Ca 2+ and reactive oxygen species (ROS) signaling pathways is well
established, with reciprocal regulation occurring at a number of subcellular locations. Many …

Summary Stromal-interaction molecules (STIM1/2) sense endoplasmic reticulum (ER) Ca 2+
depletion and activate Orai channels. However, the choreography of interactions between …

Store-operated calcium (Ca2+) entry (SOCE) occurs through a widely distributed family of
ion channels activated by the loss of Ca2+ from the endoplasmic reticulum (ER). The best …

Ca2+ signal-generation through inter-membrane junctional coupling between endoplasmic
reticulum (ER) STIM proteins and plasma membrane (PM) Orai channels, remains a vital but …

An increase in intracellular Ca2+ concentration ([Ca2+] i) controls virtually all endothelial
cell functions and is, therefore, crucial to maintain cardiovascular homeostasis. An aberrant …