Amyloid precursor protein (APP) gives rise to the amyloid-β peptide and thus has a key role
in the pathogenesis of Alzheimer disease. By contrast, the physiological functions of APP …

Mucus is integral to gut health and its properties may be affected in neurological disease.
Mucus comprises a hydrated network of polymers including glycosylated mucin proteins. We …

The ubiquitin-proteasome system (UPS) is one of the major protein degradation pathways,
where abnormal UPS function has been observed in cancer and neurological diseases …

Proteolysis of the amyloid precursor protein (APP) liberates various fragments including the
proposed initiator of Alzheimer disease-associated dysfunctions, amyloid-β. However …

Lung endothelia in the arteries, capillaries, and veins are heterogeneous in structure and
function. Lung capillaries in particular represent a unique vascular niche, with a thin yet …

Abstract Alzheimer's disease (AD), which is predicted to affect 1 in 85 persons worldwide by
2050, results in progressive loss of neuronal functions, leading to impairments in memory …

The decades of evidence that showcase the role of amyloid precursor protein (APP), and its
fragment amyloidβ (Aβ), in Alzheimer's disease (AD) pathogenesis are irrefutable. However …

Soluble amyloid precursor protein α (sAPPα), a secreted proteolytic fragment of
nonamyloidogenic amyloid precursor protein (APP) processing, is known for numerous …

Processing of amyloid beta precursor protein (APP) into amyloid-beta peptide (Aβ) by β-
secretase and γ-secretase complex is at the heart of the pathogenesis of Alzheimer's …

The amyloid precursor protein (APP), one key player in Alzheimer's disease (AD), is
extensively processed by different proteases. This leads to the generation of diverging …