Molecular and pharmacological aspects of piperine as a potential molecule for disease prevention and management: evidence from clinical trials

AK Tripathi, AK Ray, SK Mishra - Beni-Suef university journal of basic and …, 2022 - Springer
Background Piperine is a type of amide alkaloid that exhibits pleiotropic properties like
antioxidant, anticancer, anti-inflammatory, antihypertensive, hepatoprotective …

Piperine: old spice and new nutraceutical?

K Smilkov, DG Ackova, A Cvetkovski… - Current …, 2019 - ingentaconnect.com
Background: Many of the activities associated with pepper fruits have been attributed to
piperine, the most active compound present in these spices. Objective: This paper aims to …

Piperine, a bioactive component of pepper spice exerts therapeutic effects on androgen dependent and androgen independent prostate cancer cells

A Samykutty, AV Shetty, G Dakshinamoorthy… - PLoS …, 2013 - journals.plos.org
Prostate cancer is the most common solid malignancy in men, with 32,000 deaths annually.
Piperine, a major alkaloid constituent of black pepper, has previously been reported to have …

Characteristics, biological properties and analytical methods of piperine: A review

CR Quijia, M Chorilli - Critical reviews in analytical chemistry, 2020 - Taylor & Francis
Piperine (PIP) is a natural alkaloid isolated from Piper longum L. that presents antioxidant,
anticonvulsant, antimicrobial, neuroprotective, larvicidal, antiparasitic, anticancer effect and …

Quality by design‐based development and validation of an HPLC method for simultaneous estimation of pregabalin and piperine in dual drug‐loaded liposomes

I Gupta, SN Adin, M Aqil, M Mujeeb… - Biomedical …, 2023 - Wiley Online Library
The current research work describes the development of a rapid HPLC method for the
concurrent detection of pregabalin and piperine in dual drug‐loaded nanoformulations. The …

Safety aspects of the use of isolated piperine ingested as a bolus

R Ziegenhagen, K Heimberg, A Lampen… - Foods, 2021 - mdpi.com
Piperine is a natural ingredient of Piper nigrum (black pepper) and some other Piper
species. Compared to the use of pepper for food seasoning, piperine is used in food …

Lessons from black pepper: piperine and derivatives thereof

D Chavarria, T Silva, D Magalhães e Silva… - Expert opinion on …, 2016 - Taylor & Francis
Introduction: Piperine is a simple and pungent alkaloid found in the seeds of black pepper
(Piper nigrum). Following its isolation and full characterization, the biological properties of …

Bioactive Properties, Bioavailability Profiles, and Clinical Evidence of the Potential Benefits of Black Pepper (Piper nigrum) and Red Pepper (Capsicum annum) …

PV Dludla, I Cirilli, F Marcheggiani, S Silvestri… - Molecules, 2023 - mdpi.com
The consumption of food-derived products, including the regular intake of pepper, is
increasingly evaluated for its potential benefits in protecting against diverse metabolic …

Black pepper constituent piperine: Genotoxicity studies in vitro and in vivo

A Thiel, C Buskens, T Woehrle, S Etheve… - Food and Chemical …, 2014 - Elsevier
Piperine is responsible for the hot taste of black pepper. Publications on genotoxicity of
piperine are reported: negative Ames Tests and one in vitro micronucleus test (MNT). In vivo …

Simultaneous UFLC–ESI–MS/MS determination of piperine and piperlonguminine in rat plasma after oral administration of alkaloids from Piper longum L.: application …

J Liu, Y Bi, R Luo, X Wu - Journal of Chromatography B, 2011 - Elsevier
The alkaloids from Piper longum L. showed protective effects on Parkinson's disease
models in our previous study and piperine and piperlonguminine were the two main …