Hepatocellular carcinoma (HCC) is the most common primary cancer of the liver responsible
for an increasing number of cancer-related deaths, especially in developing economies of …

Hepatocellular carcinoma (HCC) is a common form of cancer that arises from hepatocytes
and whose risk may be affected by several known environmental factors, including hepatitis …

Acute intermittent porphyria (AIP) is an autosomal dominant inherited disease with low
clinical penetrance, caused by mutations in the hydroxymethylbilane synthase (HMBS) …

Homing endonucleases (HE) are double-stranded DNAses that target large recognition sites
(12–40 bp). HE-encoding sequences are usually embedded in either introns or inteins. Their …

Acute porphyrias are a heterogeneous group of metabolic disorders resulting from a
variable catalytic defect of four enzymes out of the eight involved in the haem biosynthesis …

Background: Acute intermittent porphyria (AIP) is caused by a partial deficiency of
hydroxymethylbilane synthase and affects heme biosynthesis. Mutations in the HMBS gene …

Hydroxymethylbilane synthase (HMBS) is the third enzyme involved in haem biosynthesis,
in which it catalyses the formation of tetrapyrrole 1‐hydroxymethylbilane (HMB). In this …

Hydroxymethylbilane synthase (HMBS), which is involved in the heme biosynthesis
pathway, has a dipyrromethane cofactor and combines four porphobilinogen (PBG) …

Induction of the cytochrome P450 (CYP) family of enzymes by coadministered compounds
can result in drug-drug interactions, as in the case of the coadministration of rifampicin with …

Acute intermittent porphyria (AIP) caused by mutations in the hydroxymethylbilane synthase
gene (HMBS), has been reported in almost all human populations, with varying frequencies …