Toll-like receptors (TLRs) and the nucleotide-binding domain, leucine rich repeat containing
family (or Nod-like receptors, NLRs) are two important families of microbial sensors that are …

Mycobacterium avium subspecies paratuberculosis is the causative agent of Johne's
disease, a chronic enteritis in ruminants including cattle, sheep, goats, and farmed deer …

BACKGROUND Crohn's disease (CD) has been associated with CARD15/NOD2 mutations
in Caucasians. The R702W, G908R, and 1007fs mutations represent 82% of the mutated …

Inflammatory bowel disease (IBD) is increasingly recognized as a global disease in the
twenty-first century; however, little is known about its epidemiology in Africa. We conducted a …

Background Despite a large body of literature on the subject of Crohn's disease (CD), very
little information is available on racial/ethnic differences related to disease presentation …

Observations in experimental animal models and in humans suggest that the intestinal flora
represents a great number of commensal micro-organisms that have evolved in harmony …

AIMS: To determine the factors associated with an increased C-reactive protein level in
Crohn's disease patients and to seek a correlation between the C-reactive protein value and …

AIM: To analyse allelic frequency of NOD2 gene variants and to assess their correlation with
inflammatory bowel disease (IBD) in Algeria. METHODS: We studied 132 unrelated patients …

With the emergence of the hygiene hypothesis, science has begun to reconsider the role of
bacteria in host health. Data from germ-free animals and clinical studies support the idea …

Abstract Background: The incidence of Crohn's disease (CD) has been shown to be lower in
Southern than in Northern Europe. Data on the frequency of the NOD2/CARD15 mutations …