Improved scale, multiplexing and resolution are establishing spatial nucleic acid and protein
profiling methods as a major pillar for cellular atlas building of complex samples, from …

The ability to explore life kingdoms is largely drive by innovations and breakthroughs in
technology, from the invention of the microscope 350 years ago to the recent emergence of …

Legumes form symbiosis with rhizobium leading to the development of nitrogen-fixing
nodules. By integrating single-nucleus and spatial transcriptomics, we established a cell …

Dissecting and understanding the cancer ecosystem, especially that around the tumor
margins, which have strong implications for tumor cell infiltration and invasion, are essential …

Cotton fibre is a unicellular seed trichome, and lint fibre initials per seed as a factor
determines fibre yield. However, the mechanisms controlling fibre initiation from ovule …

Callus is a reprogrammed cell mass involved in plant regeneration and gene transformation
in crop engineering. Pluripotent callus cells develop into fertile shoots through shoot …

Retrieving the complex responses of individual cells in the native three-dimensional tissue
context is crucial for a complete understanding of tissue functions. Here, we present …

In recent years, more and more single-cell technologies have been developed. A vast
amount of single-cell omics data has been generated by large projects, such as the Human …

The interactions of microorganisms among themselves and with their multicellular host take
place at the microscale, forming complex networks and spatial patterns. Existing technology …

Recent technological developments in spatial transcriptomics allow researchers to measure
gene expression of cells and their spatial locations at the single-cell level, generating …